Updated 3.26 w/ Gemini

indestructible adds:
Cascading Cataracts, [sneaky] Plaza of Heroes, Skyclave relic, Tamiyo's Safekeeping, Toski, Bearer of Secrets, {sneaky} Inspiring Call, tyvvar's stand, Gaea's Gift, Withstand death

Perfect opening:
Hickory Woodlot as land, Dark Ritual, Elvish Spirit guide, Chain of Smog, Witherbloom Apprentice, Culling the weak, Tamiyo's Safekeeping,

If setup: turn 4 Chain of Acid/Smog on indestructible land after Witherbloom apprentice is out. Cast chain against an indestructible thing, and Witherbloom will do 1 damage to oppWin

Win Combo(s):
1: Witherbloom Apprentice or Professor Onyx on the field + an indestructible permeant (land/artifact) + cast Chain of Acid on indestructible permeant causing Witherbloom Apprentice's Magecraft to trigger (gain 1 life, opponents loose 1 life). Since the target was our own item, we can copy and repeat the cycle for infinite magecraft triggers, +1 life gain triggers, and -1 opponent life triggers.

2.  Added Exquisite Blood:
Combos with Dina's/Vito's/Sanguine Bond's ability:
Whenever dealing any damage or life loss to an opponent, Exquisite Blood's ability will trigger, gaining you +1 life. Then Dina/Vito/Sanguine Bond's ability will trigger, causing the opponent to lose 1 life. This will trigger Exquisite Blood's ability again, making you gain 1 life, generating an infinite loop.

3. Added Sensei's Divining Top | Aetherflux Reservoir | Bolas's Citadel
https://commanderspellbook.com/combo/2173-4740-5078/

Simple triggers for life gain win combo, Mana confluence, Talisman, and City of Brass for tap to 1 point of damage and start the damage/life gain combo (thanks Nick).

Possible adds:

Wall of Blood +1/+1 for 20 life lost, then Dina lose 20 life sac it win the game.
Mausoleum Secrets budget tutor that is good
Dread Return reanimate 2ce. 2nd is *free well kinda.

Perfect Fit Lands: Bayou, All fetches, Leechridden Swamp (t), Overgrown Tomb (2 or t).

Removed combos:
Add Jarad and Phyrexian Devourer:
Activate the Phyrexian Devourer's ability until its death trigger is put on the stack. Hold priority and keep activating the Phyrexian Devourer's ability until its power is greater than your opponents' life totals. Pay 1BG, sacrifice Phyrexian Devourer with Jarad and win the game.

Staff of Domination in play plus:
Accomplished Alchemist - You need to gain at least 5 life for this combo to work. Tap Accomplished Alchemist to add 5 mana. Use 3 mana to untap Accomplished Alchemist with Staff of Domination, pay 1 mana to untap Staff of Domination, repeat the process to get infinite mana. With infinite mana, you have infinite draw and infinite life with Staff of Domination.