Magic Cards Against Humanity -- a party game for horrible planeswalkers. 

Each player starts with a hand of 10 cards. Roll a die to decide who goes first. At the beginning of each player's turn, that player flips up a "prompt" card and reads it out loud. The prompts can be taken from Cards Against Humanity or they can be custom-written. Then, each other player plays one of their cards face down. The active player shuffles the face down cards, flips them face up, reads them aloud, and picks the funniest answer. The player who submitted that answer gets a poison counter. At the end step, each player draws back up to 10 cards. The game ends when someone accumulates 10 poison counters, or when everyone is sick of playing.

Here are some example answers from early playtests.

Prompt: How does Nicol Bolas unwind?
Answers: Murder, Sensory Deprivation, Master of Cruelties

Prompt: The best part of waking up is _____ in your cup.
Answers: Scorching Lava, Night Soil, Frogmite

Prompt: Maybe she's born with it, maybe it's ________
Answers: Trait Doctoring, Nausea, One Thousand Lashes 

Prompt: Niv-Mizzet's favorite delicacy is _______ stuffed with _______
Answers: Sabretooth Tiger/Mental Agony, Deranged Assistant/Zebra Unicorn, Grim Backwoods/Deviant Glee

Prompt: What don't you want to find in your Chinese food?
Answers: Malicious Intent, Endless Cockroaches, Fungal Sprouting

Prompt: Jace's emo band is named _______ of ________
Answers: Fear/Goblin Test Pilot, Mind Games/Human Frailty, King Crab/Lingering Death